| Michael R Hayden | — | Buy | 2026-07-31 | 5,000 | $258K |
| Michael R Hayden | — | Buy | 2026-07-30 | 15,000 | $801K |
| Allene M. Diaz | — | Sale | 2026-07-07 | 10,111 | $864K |
| Holly B. Kordasiewicz | EVP, Chief Development Officer | Sale | 2026-07-07 | 362 | $31K |
| BENNETT C FRANK | EVP, Chief Scientific Officer | Sale | 2026-07-07 | 20,536 | $1.7M |
| Joseph Klein III | — | Sale | 2026-07-01 | 11,518 | $910K |
| Brett P Monia | Chief Executive Officer | Sale | 2026-06-26 | 50,000 | $4.0M |
| Joseph Baroldi | EVP, Chief Business Officer | Sale | 2026-06-26 | 5,635 | $452K |
| O'NEIL PATRICK R. | EVP CLO & General Counsel | Sale | 2026-06-26 | 3,069 | $246K |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale | 2026-06-26 | 26,000 | $2.1M |
| Brett P Monia | Chief Executive Officer | Sale | 2026-06-25 | 21,072 | $1.7M |
| Eric Swayze | EVP Research | Sale | 2026-06-25 | 10,602 | $839K |
| Brett P Monia | Chief Executive Officer | Sale | 2026-06-24 | 14,565 | $1.1M |
| BERTHELSEN SPENCER R | — | Sale | 2026-06-15 | 8,000 | $588K |
| Holly B. Kordasiewicz | EVP, Chief Development Officer | Sale | 2026-06-12 | 60,846 | $4.5M |
| BERTHELSEN SPENCER R | — | Sale | 2026-06-01 | 8,000 | $605K |
| Brett P Monia | Chief Executive Officer | Sale | 2026-05-14 | 3,220 | $253K |
| Brett P Monia | Chief Executive Officer | Sale | 2026-05-13 | 1,316 | $103K |
| Joseph Loscalzo | — | Sale | 2026-05-04 | 77,289 | $5.8M |
| Joseph Klein III | — | Sale | 2026-05-01 | 10,111 | $743K |
| Joseph Baroldi | EVP, Chief Business Officer | Sale | 2026-04-28 | 1,626 | $117K |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Sale | 2026-04-16 | 4,902 | $368K |
| Brian Birchler | EVP, Corp and Development Ops | Sale | 2026-04-16 | 973 | $73K |
| Joseph Baroldi | EVP, Chief Business Officer | Sale | 2026-04-16 | 5,619 | $419K |
| Lynne B Parshall | — | Sale | 2026-04-15 | 5,000 | $381K |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale | 2026-04-02 | 6,193 | $459K |
| Joseph Klein III | — | Sale | 2026-04-01 | 22,321 | $1.7M |
| Eugene Schneider | EVP, Chf Clinical Develop Ofcr | Sale | 2026-03-19 | 5,812 | $412K |
| HOUGEN ELIZABETH L | EVP, Finance & CFO | Sale | 2026-03-17 | 10,172 | $745K |
| HOUGEN ELIZABETH L | EVP, Finance & CFO | Sale | 2026-03-16 | 215,048 | $15.6M |
| Brett P Monia | Chief Executive Officer | Sale | 2026-03-10 | 34,103 | $2.6M |
| Kyle Jenne | EVP, Chf GL Pdt Str Ofcr | Sale | 2026-03-10 | 37,277 | $2.8M |
| O'NEIL PATRICK R. | EVP CLO & General Counsel | Sale | 2026-03-09 | 10,148 | $764K |
| Brett P Monia | Chief Executive Officer | Sale | 2026-03-09 | 126,670 | $9.5M |
| Joseph Loscalzo | — | Sale | 2026-03-04 | 200 | $16K |
| Joseph Baroldi | EVP, Chief Business Officer | Sale | 2026-03-04 | 439 | $35K |
| Joseph Loscalzo | — | Sale | 2026-03-03 | 832 | $67K |
| Joseph Klein III | — | Sale | 2026-03-03 | 21,332 | $1.7M |
| Allene M. Diaz | — | Sale | 2026-03-03 | 54,878 | $4.4M |
| Shannon L. Devers | EVP, Chief Human Resources Ofc | Sale | 2026-03-03 | 20,106 | $1.6M |
| BENNETT C FRANK | EVP, Chief Scientific Officer | Sale | 2026-03-03 | 85,089 | $6.7M |
| Joseph Baroldi | EVP, Chief Business Officer | Sale | 2026-03-03 | 6,220 | $496K |
| Eric Swayze | EVP Research | Other | 2026-02-27 | 256 | $13K |